Changes In Corneal Thickness And Endothelial Parameters In Patients With Diabetes Type I And II

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Laboratorinė medicina. 2015,
t. 17,
Nr. 2,
p. 58 -
64

Purpose. To compare central corneal thickness and endothelial parameters between diabetics (Type I and II), with healthy subj ects and data of Lithuanian population. To evaluate correlation with glycosylated hemoglobin and duration of diabetes.

Material and methods. 63 diabetes mellitus patients and 67 healthy subjects were examined using a non-contact specular microscope. The study parameters included age, central corneal thickness, endothelial cell density, pleomorphism, polymegathism. The duration of diabetes and glycosylated hemoglobin level were noted. Statistical analysis was performed using statistical software package (SPSS 20.0) and MS Excel with significance level a=0.05.

Results. There was almost equal proportion of men (32 (50.8%)) and women (31 (50%)) in the 63 diabettcs. The mean age was 45.5+13.3 years, duration of diabetes - 9.5+8.6 years, glycosylated hemoglobin level - 82.5+25.6 mmol/mol. 28 (44%) patients of diabetes type I, 35 (56%) -type II. Endothelial cell density was lower in diabetes type II group (2632.3+364.6 cell/mm2) than in type I (2883.7+358.3 cell/mm2; p=0.001). Central corneal thickness was higher in diabetic patients (560.7+35.7 ^m) than in control group (549+56.4 ^m; p=0.03) and mean corneal thickness of Lithuanian popula-tion (p<0.001). Endothelial cell density (2721.8+374.1 cell/mm2) was significantly lower than in control group (2960+221.1 cell/mm2; p=0.01). No correlations between glycosylated hemoglobin, duration of diabetes and any of the examined parameters were found (p>0.05).

Conclusions. Endothelial cell density in type II diabetes group is lower than in type I group. Diabetic patients have thicker corneas than in control group and Lithuanian population, but lower en do the lial cell den sity than healthy subjects.

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