Summary
Introduction. Several studies have shown that metabolic syndrome is associated with an in crease in serum uric acid.
Aim of the study. To determine the prevalence of hyperuricemia in metabolic syndrome patients and to investigate the relationship between hyperuricemia and metabolic syndrome components and other cardiovascular risk factors.
Methods. We examined 705 subjects with metabolic syndrome diagnosed using National Cholesterol Education Program Adult Treatment Panel III criteria. Serum uric acid concentration was measured for all participants. According to serum uric acid concentrations the subjects were divided into two groups: hyperuricemia group and control group.
Results. We compared values of metabolic syndrome components in these two groups. It was found that patients in hyperuricemia group consumed more alcohol, have statistically significant higher weight (p<0.001), body mass index (p<0.001), waist circumference (p<0.001), triglycerides concentration (p<0.001) and lower high-density lipoprotein cholesterol concentration (p<0.001), higher systolic (p=0.001) and diastolic (p=0.003) blood pressure, and more of them had diabetes (p=0.020) in comparison with patients with normal serum uric acid levels. However, there was no statistically significant difference between these two groups in glucose, total cholesterol, and serum low-density lipoprotein-cholesterol. The overall prevalence of hyperuricemia in patients with metabolic syndrome was 33.33%.
Conclusions. Elevated uric acid levels were observed in one-third of patients with metabolic syndrome. Subjects with hyperuricemia had statistically significant higher waist circumference, systolic and diastolic arterial blood pressure, triglyceride levels, and, conversely, lower high- density lipoprotein cholesterol. Also, more of them had diabetes, consumed alcohol, and had higher weight and body mass index.
