immunogenicity

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Summary

Background. Formation of antibodies (Ab) to TNFa blockers (adalimu-mab (ADA), etanercept (ETA) and infliximab (INF)) inversely correlates with functional drug levels and clinical effect. Comparison of drug levels and anti-drug Ab monitoring is hampered by lack of standardization.

Aim. To determine the correlation and agreement between two different assays for measurement of TNFa blockers and anti-drug Ab levels.

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