Background. The von Willebrand factor activity (VWF:Ac) assay is important in the diagnosis of von Willebrand disease (VWD), but the availability of this test is limited, because manufacturers of analyzers may not offer a possibility to measure VWF:Ac. Thus fully automated VWF:Ac system comprising reagents and analyzer by different manufacturers was implemented and verification of this ristocetin independent assay was done.
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