tėkmės citometrija

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Hereditary spherocytosis is the most common inherited red blood cell membrane disorder in individuals of northern European ancestry with an incidence of 1 case per 2000-5000 individuals. Deficiency or dysfunction of erythrocyte membrane proteins (ankyrin, band 3, α and β spectrins, protein 4.2) result in weakened interactions between the lipid bilayer and membrane skeleton leading to formation of spherocytes with decreased deformability and increased osmotic fragility. Premature splenic destruction of abnormal spherocytes is a primary cause of hemolysis in hereditary spherocytosis.

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Introduction. Endothelial microvesicles (EMV) could be potential biomarkers for early diagnosis of myocardial infarction yet their release in post myocardial infarction and association with oxidative stress largely not studied. The objective was to determine the differences in EMV numbers in patients after myocardial infarction and their association with oxidative stress in comparison with healthy controls.

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Background. Mastocytosis is a heterogeneous group of hematological disorders characterized by expansion and accumulation of clonal mast cells in one or more organs, typically the skin and bone marrow. The classification of the World Health Organization (WHO) divides the disease into cutaneous mastocytosis, systemic mastocytosis and mast cell sarcoma. The diagnosis of systemic mastocytosis is based on the criteria proposed by the WHO.

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Background and objectives. Diagnosis of myelodysplastic syndromes (MDS) is based on evaluation of blood cell counts, as well as on morphological features of hematopoietic cells and distinct cytogenetic abnormalities. As about half of cases are cytogenetically “silent” and the results of morphological analysis are sometimes indefinite there is a need for additional objective method to establish the diagnosis of MDS.

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