The Causes of Children Dyslipidemias - Single Center Experience and Review of The Literature

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Laboratorinė medicina. 2017,
t. 19,
Nr. 1,
p. 31 -
36

Objective. To determine the causes, features and relation to various risk factors of dyslipidemia in children and to provide a short review of diagnostics and treatment of dyslipidemia in children.

Material and methods. Data of children treated for dyslipidemia in Children’s Hospital, Affiliate of Vilnius University Hospital Santariskiu Klinikos (VUH SK) in 2006-2015 was analysed retrospectively. Family history, gender, age, height (us ing Holtain stadiometer), body mass, body mass index standard deviation score (BMI SDS), arterial blood pressure (BP), blood lipid (total cholesterol, low den sity li po pro tein cho les terol (LDL-Ch), high density lipoprotein choles­terol (HDL-Ch), triglicerydes (TG)) concentrations were evaluated. Lipid concentrations were measured in Children’s Hospital Clinical and Biochemistry Laboratory with COBAS INTEGRA (Roche) analyzer.

Results. The study evaluated 120 patients: 68 (56.7%) boys and 52 (43.3%) girls. Difference in boys and girls blood lipid concentration was not observed. Increased total cholesterol was measured for 69 (57.5%), LDL-Ch for 49 (40.8%), TG for 17 (14.2%) patients, decreased HDL-Ch for 18 (17.3%) patients. BMI SDS had influence on the development of hypertension (p=0.03; OR=3.5; 95 % CI 1.52-7.88). Signiftcant correlation between BMI, increased BP and hyperlipidemia was not observed. There was significant correlation (r=0.3; p=0.003) between BP and BMI. Inverse relationship between pulse pressure and HDL-Ch was observed (r=-0.3; p=0.006).

Conclusions. Dyslipidemia begins already in childhood. Risk factors for developing it are obesity, hypertension and chronic diseases. Early diagnosis, treatment and prevention of dyslipidemias for children would aid in reductng risk and severity of cardiovascular diseases.

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