Safety and Effectiveness of Correcting Dyslipidaemia in Clinical Practice

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Safety and Effectiveness of Correcting Dyslipidaemia in Clinical Practice

Egidija Rinkūnienė, Sandra Kutkienė, Zita Aušrelė Kučinskienė, Žaneta Petrulionienė, Vilma Dženkevičiūtė

 

Statins not only decrease hypercholes­terolemia, but also reduce the fre­quency of cardiovascular events, mor­tality, need for coronary arteries’ shunting and coronary angioplastics, impede the progress of atherosclerosis. However, adverse side effects, reated to statin consuming, cause concern, which results in physicians’ occasional doubts about the expedience of prescribing this medicine.

Objective. To evaluate the effec­tiveness and safety of control of dyslipidemia through the assessment of dy­namic changes of lipids, liver enzymes and creatinphosphokinase (CPK).

Material and methods. Research was performed retrospectively analyz­ing the data of 547 patients (376 male and 171 female), hospitalized in Vilnius University Hospital “Santariskiu Clinics” in the time period from 1997 to 2005, due to cardiovascular events. Mean age was 59.4 ± 10.44.

Results. Dyslipidemia I was deter­mined to 94.1% and dyslipidemia II was determined to 97.1% of patients at a time of outcome. Three months after hospitalization 90.8% of patients were still taking antilipidic drugs, afterward this number decreased. Decrease of prevalence of dyslipidemia was ob­served only during the first three months following hospitalization. Treatment of dyslipidemia was safe. Significant increase of liver enzymes was found as folfows: alanine amino­transferase - 1.7% of patients, aspar­tate aminotransferase - 0.6% of pa­tients. Significant increase of creatinphosphokinase was not determined.

Conclusions. Con sump tion of antilipidic drugs is limited, apparently due to financial resources of patients as well as particularly high cautiousness of physicians when trying to avoid ad­verse side effects of statins. Treatment of dyslipidemia was safe. However, long term monitoring and correction of dyslipidemia in Lithuania is insuffi­cient.

Keywords: dyslipidemia treatment, effectiveness, safety.

 

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