Metabolic Syndrome Diagnostics: The Importance of Serum Biomarkers and Adipose Tissue Distribution

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Fri, 2018/12/28 - 13:47
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Laboratorinė medicina. 2018,
t. 20,
Nr. 3,
p. 189 -
198

A subset of obese individuals has been described earlier, which seems to have a lower risk of cardiovascular diseases and metabolic disturbances. Mechanisms that could explain the favorable metabolic profile of these individuals are poorly understood and the exact significance of distribution of adipose tissue and associated laboratory values are still unknown.

Background. The aim of this study was to evaluate the influence of adipose tissue distribution on laboratoric biomarkers and metabolic syndrome in obese population and to establish a relationship among variables analyzed. 

Material and methods. The prospective study was performed in the Republican Vilnius University Hospital between 2014 and 2018. Anthropometric, clinical and laboratory variables were determined, subcutaneous and visceral fat thicknesses were measured by ultrasound.

Results. This study included a total of 70 obese patients (22 men and 48 women) of which 40 were with metabolic syndrome and 30 without it. Patients with metabolic syndrome had significantly higher plasma glucose, triglyceride, uric acid, insulin concentration and HOMA insulin resistance values and a thicker visceral adipose tissue. Visceral adipose tissue thickness correlated with weight, BMI, waist circumterence, glucose and uric acid concentration in plasma. Weight of 123 kg, waist circumference of 123 cm, visceral adipose tissue thickness to aorta of 8.93 cm and to vertebra of 11.53 were optimal cutoff values to predict metabolic syndrome with ROC analysis.

Conclusions. Visceral adipose tissue thickness and uric acid concentration in plasma was significantly correlated with metabolic syndrome and it’s components in obese population.

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