DIAGNOSIS OF CONGENITAL CYTOMEGALOVIRUS INFECTION BY THE BRAIN ULTRASOUND EXAMINATION: CLINICAL CASE AND LITERATURE REVIEW

You are here

Article tools
Tue, 2022/07/12 - 12:27
Downloaded: 1
Laboratorinė medicina. 2020,
t. 22,
Nr. 1,
p. 15 -
18

Summary

Introduction. Congeni tal infection with cytomegalovirus is the most common, but rarely diagnosed con gen i tal vi ral infection. The observed prevalence rate in the general population is about 0.6–0.7% of all live births, but it is not reflected in Lithuanian morbidity statistics. There is currently no existing screening for CMV of pregnant women in Lithuania and around the world. This complicates the identification of cases and potentially distorts Lithuanian statistics.

Case presentation. This article describes the clinical case of a new born who was treated in the intensive care unit right after birth. Congenital CMV was suspected by nonspecific clinical signs – respiratory dysfunction after birth, hypotrophy, thrombocytopenia and elective neurosonoscopy, that revealed changes (ventriculomegaly, lenticulo myo striatic vasopathy, insufficient gyration of Sylvian region, paraventricular calcinates). The diagnosis was confirmed by laboratory viral DNA detection in the urine. Due to early de tec tion and confirma tion of infection, it was possible to prescribe antivirus treatment with valciclovir. Further verification and development evaluation plan has been drawn up. Discussion. There is no screening of CMV infection for women in Lithuania at this time. CMV infection can be suspected during pregnancy, evaluating anamnesis, the course of pregnancy and specific echoscopic changes. Af ter birth, CMV infection can be suspected by nonspe cificclinical signs of new born: hypotrophy, microcephaly, thrombo cytopenia, early jaundice. CMV infection is confirmed by the detection of viral DNA in urine or saliva. This laboratory test is considered to be a gold standard.

Conclussions. Ultrasound examination is informative, fast, harmless, does not require special patient preparation, and specific antiviral therapy can be prescribed on time by suspicion of congenital CMV infection. This can improve the remote way out of the disease.

© 2024, Lithuanian Society of Laboratory Medicine
randomness