Blood Cytokines Concentration Reliance on Clinical Phase of Chronic Obstructive Pulmonary Disease
Virginija Šileikienė, Laimutė Jurgauskienė, Radvilė Malickaitė, Edvardas Danila
Background. COPD is complicated by frequent and reccurent acute exacerbations, which result in high mortality. Therefore it is extremely important to distiguish the nature of exacerbation (bacterial or immune). The aim of this study was to investigate peripheral blood cytokines concentration in COPD exacerbation and remission, expectantly to identify noninvasive marker of COPD exacerbation, which may help to separate infection origin of COPD exacerbation from noninfection.
Patients and methods. We meai sured plasma levels for interleukin (IL)-2, IL-4, IL-6, IL-10, tumor necrosis factor-a (TNF-a) and interferon-y (IFN-y) at exacerbation and remission of disease in 24 patients suffered from mild and severe COPD. The total count of leu ko cytes, hae mo glo bin, CRP, fibrinogen con cen tration were also evaluated. All patients underwent fibrooptic bronchoscopy and microbiologic cultures of aspitates from bronchi were investigated.
Results. The major part of our patients had bacterial exacerbation of COPD. During COPD exacerbation it was observed higher concentration of IL-10, compared with patients, who were in remission. In nonbacterial ex- ac er ba tion sub group sta tis ti cally surely higher TNF-a concentration was observed. When all patients, nondepended from exacerbation or remission, were devided in two groups by positive or negative aspirate bacteriological cultures, higher IL-10 concentration was established in positive bacteriological culture group.
Conclusion. We established, that during COPD exacerbation concentration of IL-10 was elevated by contraries concentration of TNF-a was reduced. It is seems likely that IL-10 and TNF-a can be valuable laboratory markers of COPD clini cal phase especially to distinguish bacterial exacerbation from noninfection.
Keywords: COPD, exacerbation, IL-2, IL-4, IL-6, IL-10, TNF, IFN-y.
