Summary
Background. Laboratory test results substantially impact modern medical diagnostics and treatment decisions – an estimated 50–70% of clinical decisions are based on laboratory data. Complete blood count is one of the most commonly performed diagnostic tests in pediatric practice and constitutes a critical part of routine health check-ups. Accurate interpretation of complete blood count results requires age- and development-specific reference intervals. Harmonization of pediatric hematological reference intervals remains relevant in the country’s healthcare system.
Aim. To establish reference intervals for complete blood count with automated ≥5-part leukocyte differential and cytomorphological peripheral blood smear examination in children from birth to 18 years of age. A secondary aim was to develop evidence-based recommendations for implementing these reference intervals across all national healthcare institutions following expert consensus among pediatric specialists.
Methods. This retrospective study analyzed complete blood count results obtained during preventive pediatric health check-ups. Reference intervals were calculated using two statistical approaches: the independent non-parametric method and quantile regression. A literature review was also conducted using the PubMed database with relevant keywords.
Results. Based on the analysis of retrospective data and supporting literature, age-specific reference intervals were established for complete blood count with automated ≥5-part leukocyte differential and cytomorphological blood smear in children aged 0–18 years.
Conclusions. A national consensus was reached to recommend the standardized use of pediatric reference intervals for complete blood count with automated ≥5-part leukocyte differential and cytomorphological blood smear in healthcare institutions nationwide.
