Summary
Many miRNAs have been proposed as promising molecular markers of papillary thyroid carcinoma (PTC). However, there are limited data on the correlation between miRNA expression, and neck lymph node metastasis. Analysis of miRNAs expression data may improve perioperative decision making for patients with PTC, specifically in identifying patients harboring neck lymph node metastases (LNM).
Purpose. To evaluate automated next generation sequencing SOLiD platform’s data analysis pipeline, defining accuracy, sensitivity and specificity values. Also, to evaluate used target enrichment systems (TargetSeq and SureSelect) using Sanger sequencing.
The aim. To evaluate diagnostic efficiency and clinical utility of exome sequencing in patients with epilepsy or seizures in clinical practice.
