neurotoxicity

Acute lymphoblastic leukemia is a malignant proliferation of lymphoid cells blocked at an early stage of difterentiation. It emerges after a consecutive mutations in genes important for blood cell development. Acute lymphoblastic leukemia is the most common malignancy among children. The incidence in Lithuania is 3.2-3.6 cases per 100 000 children a year. Almost 90 percent of aftected children are cured using contemporary treatment protocols, although chemotherapy caused complications can have a deleterious effect on quality of life.