Relevant animal models are essential tools to investigate in depth the patho-genesis of systemic sclerosis and search of new therapeutic interventions. Several models of scleroderma are currently available but, unfortunately, none of these reflects all features of the human disease. Some of these models present inflammation followed by fibro-sis, whether some others primarily mimic autonomous fibroblast activation. Only few models are available and suitable to study small vessels vasculo-pathy. Hence, we provide an overview of the most import ant models of systemic sclerosis.
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