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Background. Systemic sclerosis is a connective tissue disease of unknown etiology, characterized by vasculopathy, inflammation, fibrosis and production of autoantibodies. Objective of this study is to determine association of extractable nuclear antibodies and markers of vascular damage (soluble adhesion molecules ICAM-1 and VCAM-1) and inflammation (C-reactive protein and erythrocyte sedimentation rate) in systemic sclerosis.
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