Summary
Cytoplasmic granule toxins are predominantly a membrane-disrupting protein known as perforin and a family of structurally related serine proteases (granzymes) are secreted by cytotoxic CD8+ T cells and together induce apoptosis of the target cell.
Background. B-CLL is one of the most common types of leukemia. Leukemic B cells are resistant to apoptosis, and microenvironment has large impact on their survival. In this microenvironment, an important role is played by monocyte derived macrophages and the substances they secrete (e. g. cytokines). Monocytes are the pregenitors of macrophages. According to genetic and immunophenotypic differences, monocytes are categorized into 3 subpopulations.
Summary
Introduction. A proportion of patients with acute B-lymphoblastic leukemia fails to achieve a remission or does not tolerate a standardized chemotherapy. Immunotherapy with anti-CD agents might be an indispensable supplement to the treatment of these patients. The aim of the study was to investigate the expression patterns of potential immunological targets (CD20, CD22 and CD33) in patients with B-ALL.
