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Background. Mastocytosis is a heterogeneous group of hematological disorders characterized by expansion and accumulation of clonal mast cells in one or more organs, typically the skin and bone marrow. The classification of the World Health Organization (WHO) divides the disease into cutaneous mastocytosis, systemic mastocytosis and mast cell sarcoma. The diagnosis of systemic mastocytosis is based on the criteria proposed by the WHO.
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