Summary
Background. One of the main aspects in systemic sclerosis pathogenesis is small vessel vasculopathy. Capillary damage adversely affects the quality of life by causing pain, impairment of hand function and ulceration of the fingertips, which can lead to gangrene, amputations and disability. Autologous haematopoietic stem cell transplantation modifies fibrosis, activation of the autoimmune system and stabilises the function of the internal organs, but its effect on microcirculation and capillary regeneration is still largely unknown.
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