Summary
Background. With the development of health care system and scientific research, new treatment methods have emerged. Biological therapy is a new but very promising treatment method introduced for the treatment of bronchial asthma. In subsequent studies, due to the observed similarity in the pathogenesis of both diseases, biological therapy has been introduced for the treatment of chronic rhinosinusitis with nasal polyposis. Chronic rhinosinusitis with nasal polyposis is a chronic infectious allergic disease, characterized by inflammatory and hyperplastic changes in the nasal mucosa. This article presents the possibilities of biologic therapy, directed against interleukin 4 or interleukin 13, immunoglobulin E and interleukin 5, in the treatment of chronic rhinosinusitis with nasal polyposis.
Objectives. To discuss the pathologic physiology of chronic rhinosinusitis with nasal polyposis and the mechanisms of action of biological therapy, its effectiveness, and advantages in comparison with other treatment methods.
Methods. Scientific articles in PubMed, Medscape, Dovepress medical databases and the specialized information search engine Google Scholar were examined.
Conclusions. Literature review suggests that biological therapy could replace medical treatments that have traditionally relied on non-specific therapies, expand treatment options for difficult-to-control forms of the disease, and improve quality of life for patients with chronic rhinosinusitis with nasal polyposis.
