Atherosclerosis and Interleukin-1 Beta: Is the Link?

You are here

Article tools
Sun, 2013/05/12 - 16:13
Downloaded: 7
Laboratorinė medicina. 2012,
t. 14,
Nr. 4,
p. 216 -
223

Atherosclerosis and Interleukin-1 Beta: Is the Link?

Andrejus Coj, Eglė Totmianinienė

 

Summary

During the past decade, several novel risk factors for atherosclerosis (including inflammation, infections, response to vio­lation and trauma theory) have been re­ported. Cells involved in the atheroscle­rotic process secrete and are activated by soluble factors, known as cytokines and interleukin-1 (IL-1) one of the main pro- atherogenic cytokines. IL-1p primary product, 30.7 kDa amino acids protein is not active and only after proteolytic en­zyme caspase cleavage becomes active 17kDa protein. IL-ip is secretory form of IL-1. Generally physiological conditions af­fect cleavage of IL-1p N-terminal protein. In case of cell apoptosis or injury, enzymes known as trypsin, elastase, chymotrypsin, mast cells chimase, and other proteases can cleave N-terminal protein and activate IL-ip. IL-ip binding IL-1RI receptor and form complex which associate with IL-1 re­ceptor accessory protein. Only IL-ip:IL-1RI:IL-1R-AcP complex can initi­ate cell signaling paths. Inflammation and inj ury are crucial components for athero- genesis. In this article reviewed newest available data about IL-1, correspon­dence and differences of different IL-1 types, overviewed IL-1p, and looked for relation between IL-1p and atherosclero­sis. Presented data about IL-1p and in­flammation processes which affects com­plex pathways associated with inflamma- some formation, cholesterol crystal role to activate inflammation processes. Some newest experimental data about genetic polymorphisms of IL-1p and relation with atherosclerosis, IL-1p correlation with M-CSF, IL-8, IL-6, IL-1Ra and other markers also presented. Information about the LITGEN project, its main aims, tasks and plans is presented.

Keywords: IL-1p, inflammation, athero­sclerosis.

 

© 2024, Lithuanian Society of Laboratory Medicine