antibodies against erythrocytes antigens

There are known 36 red cell antigen systems and more than 600 antigens in this time. Antibodies against fetus red cells that had developed during pregnancy period can cause hemolytic desease of fetus and newborn (HDFN), although antenatal immunoprophylaxis is executed to prevent maternal-foetal anti-Rh(D) allo-immunisation. However, even severe HDFN are identified. They are caused by insufficient Rh IgG (anti-D) globulin immunoprophylaxis and other clinical significant antibodies against red cell antigens.