The aim of this paper is to evaluate the bactericidal effect of local antiseptic anti-inflammatory pharmaceuticals on respiratory tract disease causing bacteria.
Durfng 2014-2015 the Vilnius University Hospital Santariškių Clinics Microbiology laboratory identified six types of bacteria found in clinical samples collected from patient respiratory tract: H. influenzae, S. pneumoniae, M. catarrhalis, S. pyogenes, S. aureus and N. meningitidis. These bacterial cultures were used for the investigation of the bactericidal effect in vitro of local antiseptic anti-inflammatory drugs (Tantum Verde forte, Orofar, Miramile, Hexoral, Hexa-spray, Septolete Plus). The bactericidal effect of pharmaceuticals was determined by evaluating the bacteria growth inhibition zone in millimeters. The same bacteria was exposed to 20 mkl, 40 mkl, 60 mkl and 80 mkl of pharmaceuticals in the same experimental conditions. Results were obtained from the assessment of individual bacteria group reactions to all sixmedications. A cross on the evaluation of the bactericidal effect of all bacteria found that the strongest effect was characteristic to the drug Septolete Plus, i.e. Septolete Plus was the most effective at suppressing the growth of bacteria used in the study. Slightly lower efficiency was noted from drugs Hexoral and Orofar. The drugs Tantum Verde forte and Hexaspray displayed the smallest bactericidal effect and the only herbal drug used in the study differed from others by its effect, i.e. Miramile inhibited only about 70% of Staphylococcus aureus bacteria growth, while the mouth spray was effective against the rest of the five types of bacteria in the lining of the mouth. The results showed that the most resistant to drugs investigated was Staphylococcus aureus, while the most sensitive to sprays used in the study - Moraxella catarrhalis.
