Annual Report on Female Genital Mycoplasmosis and Chlamydiosis in Vilnius University Hospital Centre of Dermatovenereology

Annual Report on Female Genital Mycoplasmosis and Chlamydiosis in Vilnius University Hospital Centre of Dermatovenereology

Ona Lapteva, Jurginą Keršytė, Algimantas Paškevičius, Ingrida Buckutė Butkevičiūtė, Matilda Bylaitė

Genital mycoplasmosis and chlamydiosis are often non-symptomatic and harm re­productive system, therefore it is essen­tial to diagnose and treat them properly.

The aim of the study was to describe the epidemiology of female genital myco­plasmosis and chlamydiosis and to deter­mine antibiotic susceptibility of Urea­plasma urealyticum and Mycoplasma hominis in the Centre of Dermatovenereology in Vilnius, Lithuania, in 2010.

Matherial and Methods. One thou­sand fifty eight (1058) female visits to the Centre for sexually transmitted infec­tions (STI) were analyzed retrospec­tively.

Results. Out of 122 cultures for U.urealyticum and M.hominis, 61 were positive and antimicrobial susceptibility to macrolides, clindamycin, tetracyclines and fluoroquinolones was determined. The most common reason for seeing dermatovenereologist was referral from rheumatologist, complaint - arthralgia (44.7%). The most prevalent STI was gen­ital ureaplasmosis (314 of cases). Twenty women were positive for Chlamydia trachomatis, mostly 19-25 years old (p = 0,006). Amongst women with arthralgia incidence of ureaplasmas was greater compared to other mycoplasmas or C.trachomatis (p=0,000). U.urealyticum was isolated in 53/61 (86.9%) specimens, 7/61 (11.5%) cultures were pos i tive for both U.urealyticum and M.hominis. U.urealyticum was most sus­ceptible to azithromycin (92.5%), least - to ofloxacin (41.5%). In mixed infection specimens the highest resistance was to azithromycin (85.7%), the highest sus­ceptibility (71.4%) was to clindamycin, doxycycline and tetracycline.

In conclusion, most pafients were referred from rheumatologist, complain­ing of arthralgia and diagnosed with gen­ital ureaplasmosis. C.trachomatis was found in fewer cases, mostly amongst 19-25 years old women. In most cultures U.urealyticum was detected as single pathogen and was most susceptible to azithromycin, while ofloxacin was least effective. If U.urealyticum and M.hominis were detected, the highest susceptibility was to clindamycin, doxy­cycline or tetracycline.

Keywords: Ureaplasma urealyticum, Mycoplasma hominis, susceptibility, re­sistance, antibiotics, Chlamydia trachomatis.